POS0886 COULD BE INTERSTITIAL MYOCARDITIS A FEATURE OF THE ANTISYNTHETASE SYNDROME?

Background: Antisynthetase syndrome (ASS) is characterized by inflammatory myopathy, interstitial lung disease, arthritis, mechanical hands and Raynaud phenomenon, among other features. Recent studies have shown that idiopathic myopathies (IIM) may develop cardiac involvement, either ischemic (coronary artery disease) or (myocarditis). We wonder if characteristic involvement (interstitial appears in patients with the ASS also affect myocardial tissue. New magnetic resonance mapping techniques could detect subclinical mainly as edema (increase extracellular volume interstitium matrix), even absence of visible late Gadolinium enhancement (LGE). Objectives: Our aim was to describe presence myocarditis a group ASS. Methods: Cross-sectional, observational study performed tertiary care center. included 13 diagnosed (7 male, 53%, mean (SD) age at diagnosis 56,8 years (±11,8)). The were consecutively selected from our outpatient myositis clinic. Myositis specific associated antibodies means line immunoblot (EUROIMMUN © ). Cardiac (CMR) on all patients. protocol includes functional cine standard gadolinium (LGE), well novel parametric T1 T2 sequences (modified look locker inversion recovery - MOLLI) (ECV) calculation 20 minutes after injection gadolinium-based contrast material. Results: CMR not be one patient due anxiety. All studied (12) had normal biventricular function, without alteration segmental contraction. A third (4 out 12, 33%) showed elevated values focal LGE, half them (2/4) an ECV, consistent edema. Two unspecific LGE patterns, right ventricle union points another mild interventricular septum (Figure 1). None refer any symptomatology. four alterations (100%) but only 4 8 (50%) rest positivity. autoimmune profile follows: 10 anti-Jo1/Ro52, 1 anti-EJ/Ro52, 2 anti-PL12. Conclusion: Myocarditis, although subclinical, feature might valuable monitor these possibility same etiopathogenic mechanism involved tissue myocardium raised. More must done order assert prevalence References: [1]Dieval C et al. Myocarditis Patients With Syndrome: Prevalence, Presentation, Outcomes. Medicine (Baltimore). 2015 Jul;94(26):e798. [2]Myhr KA, Pecini R. Management Myositis: Diagnosis Treatment. Curr Rheumatol Rep. 2020 Jul 22; 22:49. [3]Sharma K, Orbai AM, Desai D, Cingolani OH, Halushka MK, Christopher-Stine L, Mammen AL, Wu KC, Zakaria S. Brief report: antisynthetase syndrome-associated myocarditis. J Card Fail. 2014 Dec;20(12):939-45. Figure 1. images Disclosure Interests: declared